Rejuran: Understanding the Skin-Healing Treatment Transforming Aesthetics

In recent years, the name Rejuran has steadily risen in conversations around aesthetic medicine, skincare innovation, and regenerative therapy. For anyone searching what Rejuran is, the answer lies in its dual promise: healing the skin at a cellular level while improving visible signs of aging. Rejuran is an injectable treatment derived from polynucleotides (PN) extracted from salmon DNA, celebrated for its biocompatibility and natural repair properties. Within the first few sessions, patients often notice improvements in skin elasticity, hydration, and texture. Unlike fillers that merely add volume or botulinum toxins that relax wrinkles, Rejuran works to heal the skin itself, setting it apart as a distinct category in aesthetic medicine. This article offers a deeply detailed look into Rejuran: how it works, its benefits, possible risks, costs, and why it has become a global trend.

The Origins of Rejuran

Rejuran traces its development to South Korea, where innovation in skincare and minimally invasive treatments often sets global standards. Researchers discovered that salmon DNA contains fragments of polynucleotides remarkably similar to human DNA, allowing it to integrate without adverse immune responses. Early clinical trials demonstrated improved wound healing, collagen stimulation, and enhanced tissue regeneration. By 2014, Rejuran was introduced as a cosmetic injectable designed to target skin damage, sun exposure, and age-related changes. Today, it is offered in aesthetic clinics across Asia, Europe, and increasingly in Western markets, often described as a **“skin healer” rather than a cosmetic quick fix.”

“We wanted a solution that doesn’t just mask aging, but actually helps the skin repair itself,” said a Seoul-based dermatologist involved in early trials.

How Rejuran Works

The science behind Rejuran centers on polynucleotides (PN). These long chains of nucleotides, when injected into the dermis, act as biological scaffolding. They:

• Stimulate fibroblasts to produce new collagen
• Improve skin elasticity by repairing extracellular matrix damage
• Enhance microcirculation for better skin tone
• Reduce inflammation, calming redness and irritation

Unlike hyaluronic acid (HA) fillers, which primarily add hydration or volume, Rejuran’s PN molecules penetrate deeper, working on the dermal repair process. Over several weeks, patients see smoother fine lines, tighter skin, and a healthier glow—effects that grow more noticeable with repeated sessions.

Types of Rejuran Treatments

To meet different skin concerns, Rejuran has evolved into several formulations:

Each treatment is tailored to a patient’s skin type, ensuring targeted and efficient outcomes.

Benefits of Rejuran

Patients often describe Rejuran’s results as subtle yet transformative. The most common benefits include:

• Improved skin elasticity and firmness
• Reduced fine lines and early wrinkles
• Better hydration for a plump, healthy complexion
• Calmer skin with reduced redness and sensitivity
• Scar improvement, particularly for acne marks
• Natural results without the “overfilled” look

“The appeal of Rejuran is its natural outcome—you look like yourself, only healthier,” notes Dr. Michelle Tan, an aesthetic physician in Singapore.

Treatment Experience: What Patients Can Expect

A typical Rejuran session takes about 30 to 45 minutes. After numbing cream is applied, the PN solution is injected using micro-needles into the dermis. Mild swelling and redness—sometimes described as “mosquito bite-like bumps”—may appear but usually subside within 24–48 hours. Results begin to surface within 2–4 weeks, with optimal improvements after 3–4 sessions spaced a month apart. Maintenance treatments every 6–12 months are recommended.

Quick Facts About the Procedure

• Downtime: 1–2 days
• Pain level: Mild to moderate
• Session frequency: Initial 3–4, then maintenance
• Suitable age: Late 20s onwards

Comparing Rejuran to Other Aesthetic Treatments

Patients often ask how Rejuran differs from well-known injectables like Botox or fillers.

Unlike Botox and fillers that work instantly but temporarily, Rejuran’s benefits accumulate gradually, addressing the underlying health of the skin.

Who Is an Ideal Candidate?

Rejuran is suitable for individuals experiencing early to moderate signs of aging, sun damage, or poor skin quality. It is particularly recommended for:

• Adults in their late 20s and above
• People with acne scars or uneven skin texture
• Those seeking natural-looking rejuvenation
• Patients with sensitive or easily irritated skin
• Individuals unwilling to undergo invasive procedures

“Patients who value subtlety and long-term skin health tend to embrace Rejuran more than quick fixes,” explains Dr. Alina Goh, a dermatologist.

Risks and Side Effects

Like any injectable treatment, Rejuran carries potential risks, though they are generally minimal. Side effects may include:

• Redness and mild swelling at injection sites
• Temporary bruising
• Rare allergic reaction (extremely uncommon due to DNA compatibility)

Most symptoms resolve within 48 hours. Choosing a skilled practitioner significantly reduces risks.

Cost Considerations

The cost of Rejuran varies by country, clinic reputation, and formulation used. On average:

• Per session cost: $300–$700
• Total initial treatment (3–4 sessions): $1,000–$2,500
• Maintenance: Once or twice yearly

Patients often view it as an investment in long-term skin health, contrasting with quick but temporary alternatives.

Global Popularity and Market Trends

Since its launch, Rejuran has seen exponential adoption across Asia, especially in South Korea, Singapore, and Thailand. Its entry into Western markets has been slower but is growing as demand for regenerative aesthetics expands. Analysts predict the global market for polynucleotide-based injectables to grow steadily over the next decade, aligning with consumer preferences for “natural yet effective” solutions.

Voices from Patients

“I didn’t want to look frozen, just fresher. Rejuran gave me exactly that—skin that looks alive again.”

“After battling acne scars for years, Rejuran S finally gave me visible improvement without harsh lasers.”

These testimonials illustrate the growing appeal of treatments that heal rather than merely conceal.

Future of Rejuran and Regenerative Aesthetics

The future of aesthetic medicine is shifting toward therapies that restore natural function. Researchers are exploring:

• Combination therapies: Rejuran with laser or microneedling
• Expanded uses: Hair restoration, scar healing beyond aesthetics
• Next-generation PN formulas with enhanced stability

Industry experts predict that regenerative injectables like Rejuran will become foundational in cosmetic dermatology.

Conclusion

Rejuran represents more than a trend—it reflects a fundamental shift in how we think about skin treatments. Instead of chasing fleeting results, it nurtures the skin’s ability to heal, restore, and maintain its vitality. For those seeking natural, science-backed rejuvenation, Rejuran provides an effective path.

FAQs

1. How soon will I see results from Rejuran?
Initial improvements appear within 2–4 weeks, with optimal results after 3–4 sessions.

2. Is Rejuran safe for sensitive skin?
Yes, it is well-tolerated even by sensitive skin, as PN molecules are biocompatible with human DNA.

3. Can Rejuran be combined with other treatments?
Yes, it is often combined with lasers, microneedling, or fillers for enhanced outcomes.

4. How long do Rejuran results last?
Results typically last 6–12 months, with maintenance sessions recommended once or twice a year.

5. Is Rejuran painful?
Discomfort is mild, managed with numbing cream; patients describe it as tolerable.